Still Alice': Julianne Moore delivers a superb performance as a woman confronting Alzheimer's

http://www.cleveland.com/moviebuff/index.ssf/2015/02/still_alice_julianne_moore_del.html

     Glen Campbell's Alzheimer's Progresses to Late Stages, Wife Says

Monday, 09 Feb 2015 09:57 AM

 

"I'm Not Gonna Miss You," from the documentary "Glen Campbell: I'll Be Me," won best country song at Sunday's show. It's nominated for best original song at the Academy Awards.

Campbell, who is battling Alzheimer's disease, didn't attend the Grammys.

"I am just so proud of him tonight ... he's been so courageous," his wife, Kim Campbell, said onstage. "Sadly, he can't be here with us because he's in the late stages."

She added: "Music I really believe kept him healthy."

The Band Perry won best country duo/group performance for their cover of Campbell's "Gentle On My Mind," which appears on the documentary's soundtrack.

Still Alice' highlights often hidden toll of Alzheimer's New York Daily News WASHINGTON — Her performance as a vibrant woman fading into the darkness of Alzheimer's is doing more than earning awards for actress ... 'Still Alice' Highlighting Often Hidden Toll of Alzheimer's - ABC News Early-onset Alzheimer's disease takes heavy toll on patients, their children - Boston Globe Full Coverage Flag as irrelevant
	Alzheimer's patients fight disease with weekly seesions KXAN.com As the haze of Alzheimer's deepens you don't realize you have entered a netherworld. But early on, you fight it and resist. Worst of all may be the ... Flag as irrelevant
	Ala family part of Alzheimer's study The Idaho Statesman "They are doing a study on the Chastain blood, because we have an extra Alzheimer's gene," she said. "They're trying to find a cure and think it's real ... Flag as irrelevant
	GPB After Alzheimer's Diagnosis, 'The Stripping Away Of My Identity' GPB When Greg O'Brien was 59 years old he was diagnosed with early-onset Alzheimer's. Now, he's documenting his experience with the disease. Flag as irrelevant
	Press of Atlantic City South Jersey residents affected by Alzheimer's on lonely vigil Press of Atlantic City By 2050, the number of people age 65 and older with Alzheimer's disease may more than triple, from 5 million to as many as 16 million, barring the ... Flag as irrelevant
	Alzheimer's Support Group Port Clinton News Herald PORT CLINTON – Magruder Hospital will host the monthly Alzheimer's Support Group at 9 a.m. Monday in the conference center. The support group ... Flag as irrelevant
	Learn warning signs of Alzheimer's Bucyrus Telegraph Forum BUCYRUS – The Alzheimer's Association, Northwest Ohio chapter, will present a program about the 10 signs of Alzheimer's disease. The program will ... Flag as irrelevant
	Windsor Star 'Still Alice' raises awareness of Alzheimer's, albeit with younger than usual face Windsor Star Moore's prize-winning performance as a college professor stricken with early-onset Alzheimer's has raised awareness of a disease with no cure. Flag as irrelevant
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	For tech support: weird text boxes appearing in posts? Alzheimers Joined: 4/5/2013. Posts: 541, I've noticed empty text boxes appearing in some posts. It just happened to me, and I was unable to edit it out. Flag as irrelevant
	Dignity Alzheimers Joined: 1/7/2014. Posts: 74. Recently I attended a get-together with my Mom and a couple of others and their LOs who were basically in the place that ... Flag as irrelevant
	Abstract Alzheimer's Research & Therapy The efficacy of a cholinesterase inhibitor, donepezil, in patients with dementia with Lewy bodies (DLB) was investigated to confirm the superiority over ... Flag as irrelevant

Lake Sunapee Region Chamber of Commerce just named YCN as Business of the Year 2014.  Congratulations.

YCN has shown and will show again the DID I DIE special on Alzheimer's, Monday l/19 at 7:30 and l0:30 as well as Tuesday 1/20 at 6:30 and 12 noon.  The special digs into relevant topics for caregivers and features professionals as well as family members taking care of those with Alzheimer's.  WYCU Comcast Channel 20 and 712 as well as Over The Air Channel 26.  WYCX Comcast channels 21 and 713.

Julianne Moore just won top actress award for her role in Still Alice.  This could help people understand Alzheimer's.  Movie out in February. 

Upper Valley Memory Cafe, a social event for people with dementia and their families and friends Saturday, January 31, 10 to 12 p.m., Novell Building, 30 Lafayette Street, Lebanon, NH.  No registration but call 603 653 3460 for more information.  Sponsored by Dartmouth Hitchcock.

Director of NIH Blogs About Our “Alzheimer’s in a Dish” Research Dr. Francis Collins is the director of the National Institutes of Health (NIH). The NIH is the principal scientific funding arm of the U.S. Government, with an annual budget of $30 billion. It provides funding for research in virtually every aspect of science. Therefore, when Dr. Collins decides to dedicate his blog to any subject from all of the potential choices available to him, particularly when it is done on an exclusive basis, that means that the subject (in this case a breakthrough) is important. Dr. Collins elected to blog about our “Alzheimer’s in a Dish” research in December. His blog post is below. — Jeff Morby, Chairman and Co-Founder, Cure Alzheimer's Fund Alzheimer's-in-a-Dish: New Tool for Drug Discovery Posted on December 9, 2014 by Dr. Francis Collins Researchers want desperately to develop treatments to help the more than 5 million Americans with Alzheimer’s disease and the millions more at risk. But that’s proven to be extremely challenging for a variety of reasons, including the fact that it’s been extraordinarily difficult to mimic the brain’s complexity in standard laboratory models. So, that’s why I was particularly excited by the recent news that an NIH-supported team, led by Rudolph Tanzi at Boston’s Massachusetts General Hospital, has developed a new model called “Alzheimer’s in a dish.” So, how did Tanzi’s group succeed where others have run up against a brick wall? The answer appears to lie in their decision to add a third dimension to their disease model.  Previous attempts at growing human brain cells in the lab and inducing them to form the plaques and tangles characteristic of Alzheimer’s disease were performed in a two-dimensional Petri dish system. And, in this flat, 2-D environment, plaques and tangles simply didn’t appear. After a series of futile attempts using a 2-D system, Doo Yeon Kim, a researcher in Tanzi’s lab, suggested the team try to grow human neural stem cells in a 3-D gel matrix. And, voila, that did the trick! The gel system allowed the cells to grow more naturally and form into 3-D networks just like they do in the brain—which, as we all know, just happens to be 3-D. Admittedly, it took a bit more than the magic of a 3-D gel to create this innovative model. The Boston team used genetic engineering to spur the neural stem cells to produce two specific proteins that are the hallmarks of Alzheimer’s disease: β-amyloid and tau. In the brains of people with Alzheimer’s, excessive accumulation of β-amyloid results in the formation of plaques in the spaces between neural cells, while tau is the main component of destructive neurofibrillary tangles within the cells. Until the latest achievement, no single model of Alzheimer’s disease simultaneously contained both amyloid plaques and neurofibrillary tangles. To demonstrate the utility of their new Alzheimer’s-in-a-dish model, the Tanzi team showed that blocking the formation of amyloid plaques with certain drugs prevents tau tangles from forming inside the neurons. This lends support to the 30-year old hypothesis that plaques are the early culprits in Alzheimer’s disease, triggering a cascade of events leading to the tangles. This finding also provides new encouragement that this category of drugs (called beta-secretases and gamma-secretases) might ultimately provide benefit to patients if given early enough in the course of the disease. In addition to the many ways in which this new model can be used to expand our understanding of Alzheimer’s disease, I’m excited about its applications for drug discovery and development. Plaques and tangles appear in this 3-D model in just six weeks, quite a contrast to the one year that it takes for plaque alone to form in a mouse model. This should greatly accelerate our efforts to screen for potential therapies that may slow, halt, or possibly even prevent the destructive march of Alzheimer’s disease throughout the brain. In fact, Tanzi plans to use his new model to test 1,200 drugs that are already approved by the Food and Drug Administration for other diseases, with the goal of seeing whether any of these drugs might be put to a new use against Alzheimer’s. He also plans to test 5,000 experimental drugs for additional leads. Hopefully, “Alzheimer’s in a dish” is just the first in a long series of success stories for modeling a wide variety of brain diseases.  In their paper in the journal Nature, the researchers say that their unique strategy should serve to facilitate the development of better models for other neurodegenerative disorders. Reference: [1] A three-dimensional human neural cell culture model of Alzheimer’s disease.  Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D’Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. Nature. 2014 Nov 13;515(7526):274-8. Source: NIH Director's Blog